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OCR: lary Approximately eighty per cent of medu ent carcinomas are sporadic and twenty per 1 dominantfamilial, the latter showing an autosom oradic inheritance with strong penetrance. In s that of a cases, the clinical presentation is usually on scan. solitary hard thyroid nodule that is 'cold Involvement of cervical lymph nodes at cent of presentation is observed in some fifty pe additional cases, when chest radiography may show involvement of the upper mediastinum Medullary carcinomas are tumours of th and occur calcitonin-secreting parafollicular C-cells es. They in males almost as frequently as in fema s of represent a different entity from tumour lls are follicular cell origin since the parent C-ce ise the derived from neural crest cells that color ultimobranchial bodies which fuse in ea w ...